KMID : 0360220220630030228
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Journal of the Korean Ophthalmological Society 2022 Volume.63 No. 3 p.228 ~ p.235
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Relationships between Symptoms and Signs of Dry Eye Using Symptom Assessment in Dry Eye Questionnaires
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Kim Ha-Ram
Oh Guan-Yeop Kim Dong-Hyun
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Abstract
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Purpose: To investigate the pattern of Symptom Assessment in Dry Eye (SANDE) questionnaire symptom scores in dry eye disease (DED) patients and to assess the relationships with several dry eye signs.
Methods: The medical records of 173 patients with DED were analyzed retrospectively. Each patient¡¯s SANDE score and history of autoimmune disease and ocular surgery were investigated, and Schirmer¡¯s test, tear film breakup time (TBUT), ocular surface staining score (OSS), tear osmolarity, and tear MMP-9 test were assessed. The distribution of SANDE scores and relationships between the SANDE score and various dry eye signs were analyzed. The relationships between the SANDE scores of TBUT (< 5 / ¡Ã 5) and OSS (< 3 / ¡Ã 3) subgroups were compared.
Results: The average SANDE score was 52.6 ¡¾ 28.1. The SANDE scores were significantly higher in OSS ¡Ã 3 than in OSS < 3 (79.1 ¡¾ 21.6 vs. 51.1 ¡¾ 27.6, p = 0.030), and TBUT ¡Ã 5 had marginally significantly lower SANDE scores than TBUT < 5 (47.2 ¡¾ 25.6 vs. 55.6 ¡¾ 29.0, p = 0.050). TBUT was significantly negatively (R = -0.151, p = 0.024) correlated with the SANDE score, while OSS was marginally significantly positively (R = 0.111, p = 0.073) correlated. As OSS increased, the SANDE scores tended to increase (p for trend = 0.008). Other dry eye signs were not associated with the SANDE score.
Conclusions: The DED symptom score from the SANDE questionnaire was related to TBUT and OSS, but there was still a discrepancy between the symptoms and signs of DED.
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KEYWORD
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Dry eye disease, SANDE, Tear film breakup time, Ocular staining score
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